Hemostasis How Your Blood Clots Overview

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Platelets are called thrombocytes "cells of thrombus".

The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.

When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).

After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.

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To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. If you like my videos, please consider leaving a tip at paypal.me/perfectionalis/
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Como educador, estou profundamente engajado no desenvolvimento dos estudantes em ambiente escolar, adotando métodos pedagógicos que valorizam conexões genuínas e são movidos por inovação e fervor. É minha vocação guiar os alunos na jornada de se tornarem uma geração notável, empregando estratégias de ensino amplamente aclamadas por prestigiadas instituições acadêmicas ao redor do globo - perfume.rukahair.com